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Gabapentin: risk of severe respiratory depression

25th October 2017

The MHRA has highlighted a rare risk of severe respiratory depression in patients taking gabapentin even without concomitant opioids. Dose adjustments may be necessary in patients at higher risk of respiratory depression, including the elderly, those with compromised respiratory function, respiratory or neurological disease, renal impairment, or taking other CNS depressants. This advice follows a European review and the SPC for gabapentin is being updated. 

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